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Disubstituted pyrimidines as Lck inhibitors

Julianne A. Hunt,Richard T. Beresis,Joung L. Goulet,Mark A. Holmes,Xinfang J. Hong,Ernest Kovacs,Sander G. Mills,Rowena D. Ruzek,Frederick Wong,Jeffrey D. Hermes,Young-Whan Park,Scott P. Salowe,Lisa M. Sonatore,Lin Wu,Andrea Woods,Dennis M. Zaller,Peter J. Sinclair

Bioorganic & Medicinal Chemistry Letters（2009）

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摘要
Compound 4 was found to be a potent inhibitor of Lck activity (IC50=0.1nM) and cellular IL2 release (IC50=8nM).
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关键词
Lck,Src,Protein tyrosine kinase,Autoimmune disease,Rheumatoid arthritis,Pyrimidine
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