145 Cardiac magnetic resonance based assessment of cardiac work by pressure-volume and stress-length relation in patients with dilated cardiomyopathy and aortic valve stenosis

Introduction Dilated cardiomyopathy (DCM) is characterized by left ventricular (LV) dilatation of unknown cause. It remains unresolved whether a reduced cardiac performance results primarily from dilatation or impaired cardiomyocyte contractility. In experimental animals, cardiac work is derived from pressure-volume area and analyzed further using stress-length relations. We hypothesized that not only pressure volume loops but also stress-length diagrams can be derived from cardiac volume and cardiac mass as assessed by CMR and invasively measured pressure.