化疗药物渗漏对大白鼠皮肤副反应及处理方法的研究
Sichuan Journal of Cancer Control(2007)
Abstract
目的:运用大白鼠模型探讨三种化疗药物所致的皮下损伤的病理过程、分级标准及最佳处理方式。方法:将126只大白鼠随机分成两组,一组用丝裂霉素、阿霉素、诺维本处理后观察病理过程,另一组用上述三种药处理后分别用10%硫代硫酸钠、0.5%普鲁卡因+地塞米松,0.5%普鲁卡因+地塞米松+硫代硫酸钠解救并记录结果送病检。结果:硫代硫酸钠解救丝裂霉素、阿霉素有效,地塞米松有明显减轻局部反应的作用,“V”字形封闭优于环状封闭。结论:临床可用硫代硫酸钠解救丝裂霉素、阿霉素所致的渗漏,用新的分级标准可用来评价化疗药物渗漏反应轻重程度。
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Key words
Rat Model,Drug Leakage,Relief,Pathological Process,Chemotherapy Drug
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