Application Of An Automated Hs-Gc Method In Partition Coefficient Determination For Xylenes And Ethylbenzene In Rat Tissues

An automated static head space-gas chromatography method was used in the determination of partition coefficients (K-d) for the xylene isomers and ethylbenzene in blood, brain, muscle, kidney, liver and fat of Sprague Dawley rats. Since homogenization resulted in the potential loss of analytes from tissue samples, unhomogenized samples were used. With a few exceptions, tissue:air K-d values were independent of the concentrations of the analytes, singly or as a mixture. The tissue:blood K-d values were determined. For each tissue and analyte, the value obtained for each analyte concentration was within +/- 10% of the mean value calculated for the entire concentration range. Crown copyright (C) 1998 Published by Elsevier Science Ltd. All rights reserved.