The long-term effects of pancreatectomy on the Ca metabolism of the rat
Acta diabetologica latina(1983)
摘要
Summary The Ca metabolism of pancreatectomized (PX) rats was investigated three months after surgery. Most PX animals were in negative
Ca balance because of increased endogenous fecal Ca excretion and reduced true Ca absorption. Significant increases were also
observed in bone Ca resorption rates, hydroxyproline excretion and size of osteocyte lacunae. Inverse correlations between
the rates of bone Ca resorption and Ca balance were observed in the PX and control groups. Significantly, both correlations
were found to fit the same function. It was concluded that parathyroid hormone secretion and its metabolic expression were
not impaired by pancreatectomy. The coupling between bone Ca accretion and resorption was absent in PX animals: high resorption
rates were found associated with normal or decreased accretion rates. These latter rates, in combination with the negative
Ca balance, explain the reduction in the skeletal Ca mass.
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关键词
control group
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