家兔体内思密达对左氧氟沙星药动学的影响
China Pharmacy(2008)
Abstract
目的:探讨口服思密达和左氧氟沙星后左氧氟沙星的药动学有无改变。方法:取家兔6只随机交叉(间隔1周)经口灌胃左氧氟沙星(A组)、左氧氟沙星+思密达(B组)、左氧氟沙星2h后+思密达(C组)。采用高效液相色谱法测定不同时间血样中左氧氟沙星浓度,计算并比较药动学参数。结果:A组与C组比较,Cmax、tmax、AUC、t1/2均无显著性差异(P>0.05);B组除tmax与其它组无差异外(P>0.05),t1/2延长,AUC、Cmax值降低(P<0.05)。结论:同时使用左氧氟沙星和思密达,可明显改变前者的药动学参数;使用左氧氟沙星2h后再用思密达,此用药方案较为合理。
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Key words
Interaction,Levofloxacin,Serum drug concentration,Pharmacokinetics parameters,Smecta
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