The analysis of SRY gene deletion and SOX9 gene exon1 partial deletion on malesexual abnormality

Objective:To study SRY gene and SOX9 gene′s clinical value in diagnosis for the patients with sexual abnormality.Methods: Chromosomes analysis and amplify the SRY gen and SOX9 gene exon1 with PCR.Results: The chromosomes of two cases is not abnormal;the SRY gene of case1 is deletion,and the SOX9 gene exon1 is not abnormal;the SRY gene of case2 is not abnormal and SOX9 gene exon1 is partial deletion.Conclusion:The deletion of SRY gene plays a certain role in case1′s sexual abnormality and the SOX9 gene exon1 partial deletion plays a certain role in case2′s sexual abnormality.