Effects of IL-12 gene therapy on spontaneous transgenic and transplanted breast tumors
Breast Cancer Research and Treatment(2007)
摘要
Cytokines are promising agents for cancer therapy due to their activity at low concentrations. We used a naked IL-12 DNA expression vector to achieve long-term systemic cytokine expression to inhibit breast tumor growth in MMTVneu transgenic and transplanted models. Constant low levels of IL-12 produced by this protocol provided effective tumor growth inhibition of both tumor models without adverse effects.
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关键词
IL-12,gene therapy,MMTVneu,transgenic mice,transplanted breast tumors
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