Finding Significant Patterns Characterizing Types of Alternative Splicing

Alternative pre-mRNA splicing events can be classied into various types, including cassette, mutually exclusive, alternative 3' splice site, alternative 5' splice site, retained intron (3). The detection of regulatory sequence elements closely related to such a particular type of alternative splicing events is an important and challenging problem in understanding the mechanism of alternative splicing. However, it seems that it has not been given enough extensive computational analysis of examining whether there are candidate regulatory sequence elements characterizing types of alternative splicing events. In this work, we consider the problem of nding signican t patterns specic to the types of alternative 5' splice site, alternative 3' splice site, and cassette, respectively, from their alternative exons and anking introns.