Macrophage Functions in Beige (Chédiak-HigashiSyndrome) Mice1
msra(1980)
摘要
Beige (C57BL/6J-bgJ/bgJ) mice are the murine counterpart of the Chédiak-Higashisyndrome, exhibiting abnormal lyso- somes in phagocytes. These mice, however, responded nor mally to Corynebacterium parvum killed bacterial vaccine with splenomegaly and an increase in peritoneal macrophages. The C. parvum-elicited macrophages showed normal immunoglob- ulin G Fc- and C3b-mediated rosettes and phagocytosis. The antitumor action of the macrophages was assessed against the Lewis lung carcinoma, a tumor that is sensitive to inhibition by activated macrophages both in vitro and in vivo. The elicited macrophages from beige mice showed delays in vitro in cyto- static and cytotoxic activity against the tumor cells, as com pared with C57BL/6J-+/+ control mice. The early delays in activity disappeared after 12 to 24 hr, when antitumor activity was similar to that exhibited by C. parvum-elicited macro phages of the C57BL/6J-+ / + mice. These delays in antitumor activity of beige mouse macrophages may be analogous to the delays observed in the bactericidal activity of beige mouse granulocytes. The ultimate antitumor activity, however, was comparable in beige and +/+ C. parvum-elicited macro phages. Moreover, the resistance of mice in vivo to the Lewis lung tumor was not markedly impaired. The growth of the primary tumors and the mean times to death of the tumor-
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关键词
bearing animals of both strains were similar.
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