Synthesis and evaluation of new 2′,3′-dideoxynucleoside analogs as potential anti-AIDS and anti-herpes drugs

Abdesslem Faraj,M Maillard,Marc Lemaitre,S Letellier,Francois Frappier,J C Florent,David S Grierson,Claude Monneret,Aurelio Zerial

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY（1992）

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摘要

Based on the known structure-activity relationships for the active anti-HIV, a series of 3'-deoxy-3'-N-functionalized thymidine analogs has been synthesized from thymidine. Evaluation for inhibitory activity against human immunodeficiency virus (HIV) replication in CEM cells and against herpes simplex virus in MRC-5 cells is reported.

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关键词

ANTI-HERPES DRUG,2',3'-DIDEOXYNUCLEOSIDE ANALOG,ANTI-HIV

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