Les chimiokines dans les réactions allergiques cutanées : le modèle SCID, un outil puissant pour évaluer leur intérêt comme cibles thérapeutiques

Chemokines are small chemotactic molecules actingthrough G-protein-coupled receptors. Their functions are very diverse in homeostatic as well as in inflammatory conditions. Recently, it has been shown that chemokines and their receptors also help control the tissue specificity of memory lymphocyte subsets, which could lead to their use as therapeutic targets in selective tissue diseases such as allergic cutaneous reactions. Currently available animal models are not relevant to the human situation, which is a reason as to why we have developed an in vivo model of humanized immunodeficient mice grafted with human skin and mononuclear cells. This model will allow us to evaluate, in a pre-human context, the bonafide effects of chemokines and to test them as potential therapeutic targets.