Autoantibodies against aggrecan in systemic rheumatic diseases

D.H. Vynios,I. Tsagaraki,G.H.A. Grigoreas,M. Samiotaki,G. Panayotou,D. Kyriakopoulou,P. Georgiou,D. Korbakis,A. Panayotou,K. Nanouri,M. Assouti,A.P. Andonopoulos

Biochimie（2006）

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摘要

Objective. – This study was undertaken to investigate the presence of autoantibodies against the main cartilage proteoglycan, aggrecan, in systemic rheumatic disease sera, and to identify substructure(s) responsible for the autoimmune response.

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关键词

Anti-aggrecan autoantibodies,Systemic rheumatic diseases,ELISA,G2 aggrecan domain,Hyaluronan-binding region

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