Evaluation of myocardial matrix metalloproteinase (MMP) mediated post-MI remodeling with a novel radiolabeled MMP inhibitor

Background: Myocardial matrix metalloproteinases (MMPs) play an important role in post myocardial infarction (MI) left ventricular (LV) remodeling. The administration of MMP inhibitors may prevent post MI remodeling. The use of a radiolabeled MMP inhibitor targeted at MMPs could provide a novel approach for evaluation of the temporal changes in MMP activation and localization post-MI, which could guide therapy.