Atomic Force Microscopy In Nanomedicine
BIOSYSTEMS INVESTIGATED BY SCANNING PROBE MICROSCOPY(2010)
Abstract
The combination of AFM with conventional techniques, as well as AFM itself, allows answering biomedical questions of high
interest. We could show this clearly for CFTR with single molecule imaging and observation of structural dynamics in native
cell membranes. AFM also allows identification and determination of CFTR at single molecule level. The observation that the
lack of CFTR influences the mechanical and, therefore, rheological properties of RBC could lead to a novel therapeutic approach
for CF treatment. Regarding the fact that the defect of a single protein causes lethal diseases, research at the single molecule
level would become vital in the future.
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