Clinical investigation on early infections after hematopoietic stem cell transplantation

Objective To investigate the clinical characters of early infections after hematopoietic stem cell transplantation(HSCT).Methods The clinical data of 36 cases of early infections after hematopoietic stem cell transplantation from Jan 2001 to Jul 2006 were analyzed.Results Infection after transplantation occurred in 31 patients(86.1%).The main pathogens of the early stage were microbes,among which 23.8% were Gram positive and 71.4% were Gram negative.Infection occurred mainly in respiratory tract(54.1%),followed by oral cavity,intestinal tract and skin.No infection focus was found in 3 cases.There existed no significant difference in infection incidence rate between patients complicated with acute graft versus host disease and without.Conclusions There is a high infection incidence rate for patients in early stage after HSCT.The pathogens are mainly Gram-negative bacteria.A reasonable use of antibiotics and preventing the fungal infection are good ways to control early infections after HSCT.