Anti-Hiv Activity Of Quassinoids

Masayoshi Okano,Narihiko Fukamiya,Kiyoshi Tagahara,Mark Cosentino,Thomas Tung-Ying Lee,Susan Morris-Natschke,Kuo-Hsiung Lee

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS（1996）

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摘要

Eighteen quassinoid glycosides and nine known quassinoids were tested for inhibitory activity against HIV replication in H9 lymphocytic cells. Of the compounds tested, shinjulactone C (20) demonstrated the highest anti-HIV activity (EC(50) = 10.6 mu M) in the absence of cytotoxicity with a therapeutic index of >25.

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therapeutic index

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