Pharmacological characterization of vasopressin aggregation response of human platelets

Vasopressin has been reported to induce aggregation of human and dog platelets but not those of rabbit or pig (11. Vasopressin is generally recognized to have two distinct receptor subtypes associated with its respective vasoconstrictor (VII and antidiuretic (Vtl activities. In previous studies which used both platelet aggregation and binding studies in platelet membranes to characterize the vasopressin subtype pharmacologically, several groups have concluded it is of the V, subtype (2,3,5 and 61 while one group concluded the receptor subtype was Vf (41.