Antidiabetic Activity Of Spondias Mombin Extract In Niddm Rats

The antidiabetic activity of the methanol leaf extract of Spondias mombin Linn (Anacardiaceae), a medicinal plant used in the treatment of diabetes and other diseases, was evaluated in oral glucose tolerance test and alloxan induced diabetic rats using the O-toluidine and glucose-oxidase methods. A dose of the methanol extract and its chloroform fraction was administered to experimental diabetic rats and their blood glucose levels evaluated over 8 h. The extract exhibited significant blood glucose lowering effect in the oral glucose tolerance test and the alloxan induced diabetic rats when compared with the control. The chloroform fraction of Spondias mombin showed a peak hypoglycaemic effect of 60.6% at 4 h. This study, therefore, justifies the use of the plant in the treatment of diabetes mellitus.