Discovery of MK-7246, a selective CRTH2 antagonist for the treatment of respiratory diseases.

Bioorganic & Medicinal Chemistry Letters（2011）

引用 48|浏览52

暂无评分

摘要

In this manuscript we wish to report the discovery of MK-7246 (4), a potent and selective CRTH2 (DP2) antagonist. SAR studies leading to MK-7246 along with two synthetic sequences enabling the preparation of this novel class of CRTH2 antagonist are reported. Finally, the pharmacokinetic and metabolic profile of MK-7246 is disclosed.

查看译文

关键词

MK-7246,CRTH2 antagonist,DP2 antagonist,Asthma,Respiratory diseases

AI 理解论文

溯源树

样例

生成溯源树，研究论文发展脉络

Chat Paper

正在生成论文摘要