Korundamine A, A Novel Hiv-Inhibitory And Antimalarial "Hybrid" Naphthylisoquinoline Alkaloid Heterodimer From Ancistrocladus Korupensis

Yali F. Hallock,John H. Cardellina,Manuela Schäffer,Gerhard Bringmann,Guido François,Michael R. Boyd

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS（1998）

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摘要

A unique heterodimeric naphthylisoquinoline alkaloid, korundamine A (2), comprised of two different monomeric biaryl halves, has been isolated from the Cameroonian tropical liana Ancistrocladus korupensis. Korundamine A is the first "hybrid" dimer found in the Ancistrocladaceae; rr! vitro, it demonstrated anticytopathic activity against HIV-1 and antimalarial activity against Plasmodium falciparum. Published by Elsevier Science Ltd.

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