Alkyne-quinuclidine derivatives as potent and selective muscarinic antagonists for the treatment of COPD.

Jean-Philippe Starck,Laurent Provins,Bernard Christophe,Michel Gillard,Sophie Jadot,Patrick Lo Brutto,Luc Quéré,Patrice Talaga,Michel Guyaux

Bioorganic & Medicinal Chemistry Letters（2008）

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摘要

SAR around alkyne–quinuclidine derivatives allowed the discovery of highly potent muscarinic antagonists displaying interesting preferential slow off-rates from the M3 receptor.

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关键词

Muscarinic receptor(s),COPD,Quinuclidine

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