Familial Atypical Mole Melanoma (Famm) Syndrome
PRINCIPLES OF CLINICAL CANCER GENETICS: A HANDBOOK FROM THE MASSACHUSETTS GENERAL HOSPITAL(2010)
Abstract
The incidence of cutaneous melanoma continues to increase rapidly worldwide. In the United States alone, the incidence of
melanoma has been roughly doubling each decade, and according to the most recent projections by the American Cancer Society
and the National Cancer Institute Surveillance, Epidemiology, and End Results (SEER), it was estimated that 1 in 41 Americans
would develop melanoma in their lifetime. In 2009, 68,720 new cases of melanoma were diagnosed, with 8,650 deaths attributable
to the disease [1].
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Key words
Melanoma,Atypical mole,p16 gene,CDKN2 gene,Cell cycle
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