Figure S7 from ⁸⁹Zr-ImmunoPET for the Specific Detection of EMP2-Positive Tumors

S7. ImmunoPET imaging with 89Zr-DFO- anti-EMP2 mAb of U87MG/EMP2Fluc or sham injected nude mouse in an intracranial model. All mice received the same surgical procedures, but they were injected with either U87MG/EMP2Fluc cells or saline (sham treated). A. Bioluminescence imaging showing the presence of intracranial U87MG/EMP2Fluc cells or no cells in the sham in a representative set of animals. B. Maximum intensity projection (MIP) images were acquired at 24 and 120 hours post-intravenous injection of 89Zr-DFO-anti-EMP2 mAb in a representative animal injected with U87/EMP2Fluc vs sham treated animal. C. In vivo biodistribution of sham mice at 120 hrs indicate that there was no measurable uptake of 89Zr-DFO-anti-EMP2 mAb in the brain. N=2.