Preparation and biological evaluation of key fragments and open analogs of scleritodermin A
Tetrahedron(2010)
Abstract
The synthesis of key fragments of scleritodermin A, their assembly, and their biological evaluation as cytotoxic and anthelmintic were performed. Highlights of the synthetic route include formation of the α-ketoamide linkage and use of stereocontrolled reactions. Open analogs of this natural product were obtained using a convergent strategy.
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Key words
Scleritodermin A analogs,Key fragments,α-Ketoamide,Azoles
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