Inhibitory Effect of Sorafenib Combined with Hyperthermia on the Proliferation of Human Hepatocellular Carcinoma Cells Line HepG-2

Objective To observe the inhibitory effect on the Proliferation of HepG-2 cells by the treatment of sorafenib combined with hyperthermia.Methods The Proliferation of HepG-2 cells was determined by MTT assy after administration with sorafenib alone,hyperthermia alone or sorafenib in combination with hyperthermia.Results Either sorafenib or hyperthermia had an inhibitory effect on HepG-2 cells and sorafenib combined with hyperthermia revealed a synergistic effect(P0.01).The efficacy in patients receiving sequential chemotherapy with sorafenib was similar to that in patients receiving sequential chemotherapy with hyperthermia(P0.05).The inhibitory effect was higher in the dual-therapy group than in the monotherapy groups(P0.01).The inhibitory effect was higher in sorafenib combined with hyperthermia than the sequential chemotherapy(P0.01).Conclusions Sorafenib or hyperthermia alone has an inhibitory effect on the proliferation of HepG-2 cells.Simultaneous administration with sorafenib and hyperthermia has a synergistic effect.Sequential chemotherapy is higher than the sorafenib or hyperthermia alone.