1,4-Bis(alkylamino)benzo[g]phthalazines able to form dinuclear complexes of Cu(II) which as free ligands behave as SOD inhibitors and show efficient in vitro activity against Trypanosoma cruzi.

Marinela Rodríguez-Ciria,Ana M Sanz,María J R Yunta,Fernando Gómez-Contreras,Pilar Navarro,Manuel Sánchez-Moreno,Samira Boutaleb-Charki,Antonio Osuna,Alfonso Castiñeiras,Mercedes Pardo,Carmen Cano,Lucrecia Campayo

Bioorganic & Medicinal Chemistry（2007）

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摘要

The synthesis of a new series of benzo[g]phtalazine derivatives is reported, and the complexating ability of these compounds towards Cu(II) might be connected with their SOD inhibitory activity in Tripanosoma cruzi.

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关键词

1,4-Bis(alkylamino)benzo[g]phthalazines,Trypanosoma cruzi SOD inhibitors,Dinuclear copper complexes,OH endogenous bridges,Antiparasitic activity

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