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Antihypertensive benzopyran-related potassium channel activators: a role for lipophilicity

Richard M. Soll,Dominick A. Quagliato,David D. Deininger,Paul J. Dollings,Betsy L. Joslyn,Terrence M. Dolak,Sung J. Lee,Chris Bohan,Alexandra Wojdan,Mary Ellen Morin,George Oshiro

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS（1991）

Cited 8|Views10
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Abstract
A series of benzopyran-related potassium channel activators were prepared and evaluated at the calculated ED30 dose in the spontaneously hypertensive rat. The duration of the blood pressure lowering effect was found to be related to the lipophilicity of the agent and was independent of the potency.
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potassium channel
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