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Estrogen receptor ligands. Part 8: Dihydrobenzoxathiin SERAMs with heteroatom-substituted side chains

Timothy A Blizzard,Frank DiNinno,Jerry D Morgan,Jane Y Wu,Helen Y Chen,Seongkon Kim,Wanda Chan,Elizabeth T Birzin,Yi Tien Yang,Lee-Yuh Pai,Zhoupeng Zhang,Edward C Hayes,Carolyn A DaSilva,Wei Tang,Susan P Rohrer,James M Schaeffer,Milton L Hammond

Bioorganic & Medicinal Chemistry Letters（2004）

Cited 32|Views21
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Abstract
A series of benzoxathiin SERAMs was prepared. Minor modifications in the side chain resulted in significant effects on biological activity, especially in uterine tissue.
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Key words
SERMs,SERAMs,Estrogen
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