Solid phase synthesis of chiral 2-amino-benzimidazoles
Tetrahedron Letters(2001)
Abstract
A multi-step solid phase synthesis of 2-aminobenzimidazoles is described. The reaction sequence incorporates optically active α-amino acids to afford enantiomerically pure 2-aminobenzimidazoles with a chiral center adjacent to one of the heterocyclic nitrogens. This solid phase methodology has been further extended to prepare other chiral heterocyclic compounds such as benzimidazolones.
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Key words
nitrogen,optical activity,amino acid
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