Progressing Neural Stem Cell Lines to the Clinic
Stem Cell Research and Therapeutics(2008)
摘要
In recent years, prospects for treating serious neurological disorders have improved with the development of cell therapy
as a viable therapeutic strategy. Initial clinical studies on cell implantation therapy in the brain used primary fetal tissue
but progress has been made in developing expanded cell lines from somatic neural stem cells and embryonic stem cells. In addition,
neural stem cell lines have been established by means of genetic modification to generate immortalized clonal lines including
the use of conditional immortalization. These cells and cell lines provide the raw materials for the manufacture of investigational
medicinal products for use in early clinical trials. The use of conditional immortalization technologies is particularly attractive
for cell therapy products by enabling long term expansion. Cell lines for therapeutic application in neurological disease
have been developed by ReNeuron using the c-mycER technology including one line, CTX0E03, that is in late pre-clinical development
for the treatment of stroke.
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关键词
regulatory issues,neurodegenerative disease,stem cells,immortalizing technology,implantation
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