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Myocardial function in hearts with transgenic overexpression of the G protein-coupled receptor kinase 5.

Edward P Chen,Hartmuth B Bittner,Shahab A Akhter,Walter J Koch,R Duane Davis

The Annals of Thoracic Surgery（2001）

Cited 50|Views5
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Abstract
Background. Chronic heart failure is associated with impairment of the myocardial β-adrenergic receptor (β-AR) system. In this study, the effects of G protein–coupled receptor kinase 5 (GRK5) overexpression on myocardial performance were directly assessed in the hearts of transgenic mice using an isolated work-performing murine heart preparation and computerized analysis of functional data.
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Key words
cardiac output,control group,stroke volume,transgenic mice,g protein coupled receptor,cardiac function,adrenergic receptor
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