Effect of “profetal” on differentiation and functional activity of human mononuclear leukocytes

The effect of “Profetal”, a preparation containing human α-fetoprotein, on proliferative activity and differentiation of mononuclear leukocytes isolated from donor peripheral blood was studied in cultures with serum-free media. The results suggest that human α-fetoprotein in effective doses stimulates proliferation and blast transformation of cultured peripheral blood mononuclear leukocytes with the formation of CD34 + /CD45 + hemopoietic precursor cells. This phenomenon of ex vivo generation of hemopoietic precursor cells using human α-fetoprotein can be important for clinical oncology, specifically, for the development of adaptive cell therapies.