The influence of neonatal jaundice on HBV vaccination.

Objective To study serum antibody conversion after the second dose of HBV vaccination in infants with neonatal jaundice.Methods Among 615 infants with neonatal jaundice,308 of which were vaccinated with standard schedule and the others were vaccinated with the second dose of HBV vaccine after the clearance of jaundice.The serum anti-HBs concentration was tested by RIA method.Results The anti-HBs positive rate was 86.1% on average.The proportion of anti-HBs serum conversion was significantly lower in the group with the standard schedule of the second dose of HBV vaccine(80.9%)than that in the group with the second dose of HBV vaccination after the clearance of neonatal jaundice(91.8%,P0.05).Conclusion The neonatal jaundice was associated with the failure of HBV vaccination.The result suggested that the second dose of HBV vaccination should be postponed in infants with delayed clearance of neonatal jaundice.