ChemInform Abstract: Synthesis of Isomelamines and Isocyanurates and Their Biological Evaluation.

The reaction of cyanogen bromide (1) with primary amines (2a-p), including arylmethylamines (2l-p), gave the corresponding cyanamides (3a-p). Trimerization of 3a-p gave 1, 3, 5-trisubstituted 2, 4, 6-triiminohexahydro-1, 3, 5-triazines (isomelamines) (4a-p), which were treated with hydrochloric acid to give the corresponding 1, 3, 5-trisubstituted 2, 4, 6-trioxohexahydro-1, 3, 5-triazines (isocyanurates) (5a-c, f) and 1, 3, 5-trisubstituted 2-imino-4, 6-dioxohexahydro-1, 3, 5-triazines (5b'-e'). Biological evaluation of 4a-p, 5a-c, f, and 5b'-e' was carried out, and some of these compounds showed bronchodilator and positive inotropic activities.