Human Rnase P And Transcription
RIBONUCLEASE P(2010)
摘要
Human nuclear RNase P has been initially characterized by virtue of its ability to process the 5′ leader sequence of precursor
tRNA. This ribonucleoprotein complex consists of H1 RNA subunit and at least ten distinct protein components. However, recent
findings reveal that RNase P has a role in transcription by RNA polymerase I (Pol I) and Pol III. RNase P associates with
these two polymerases, binds to chromatin of rDNA, 5S rRNA and tRNA genes, and determines the transcriptional output of these
polymerases in the nucleus. The molecular mechanism(s) by which RNase P acts on transcription are being investigated. This
essay summarizes some aspects of old and new functions of this remarkable ribonucleoprotein.
更多查看译文
AI 理解论文
溯源树
样例
![](https://originalfileserver.aminer.cn/sys/aminer/pubs/mrt_preview.jpeg)
生成溯源树,研究论文发展脉络
Chat Paper
正在生成论文摘要