2-Substituted-4-Methoxybenzimidazole-Based Pde4 Inhibitors

J Regan,J Bruno,D McGarry,G Poli,B Hanney,S Bower,J Travis,D Sweeney,B Miller,J Souness,S Djuric

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS（1998）

引用 16|浏览15

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摘要

A new family of PDE4 inhibitors based on a benzimidazole framework is described. Several of these compounds are orally bioavailable and show efficacy in in vivo models of inflammatory disease. (C) 1998 Elsevier Science Ltd. All rights reserved.

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关键词

inhibitors,methoxybenzimidazole-based

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