Hemoglobin vancouver [α2β2 73(E17) Asp→ Tyr]: Its structure and function
JOURNAL OF MOLECULAR EVOLUTION(1976)
摘要
Summary Hemoglobin Vancouver is a new abnormal hemoglobin with an amino acid substitution of the normal aspartyl residue 73 of theß chain by a tyrosyl residue. It was discovered in a man of Chinese descent in association withß thalassemia. It was subsequently detected in a sister in association with normal Hb A. The oxygen affinity of the abnormal hemoglobin is decreased but its subunit interaction is normal. The Bohr effect may be slightly increased.
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关键词
abnormal human hemoglobin,structure and function,amino acid substitution
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