Effect of Different Administration Route of Antibiotics on Therapeutic Efficacy after Laparoscopic Cholecystectomy

OBJECTIVE:To evaluate the effect of different administration route of antibiotics on therapeutic efficacies after laparoscopic cholecystectomy (LC) in our hospital.METHODS:200 LC patients in our hospital were selected during 2008-2009 and randomly divided into group A and B,100 patients in each group.Group A was given antibiotics i.v.,and group B was given oral antibiotics for 3 days.After clinical observation,outpatient or telephone interviews were conducted to investigate the incidence of postoperative infectious one month later.The bile of 200 patients were collected,and the germiculture was carried out.RESULTS:3 patients in Group A were infectious complication (3%),wound infection in 2 patients and urinary tract in one.4 patients in Group B were wound infection.The incidences of postoperative infection were not significantly different between two groups(P0.05).90 bile samples had a positive result with positive rate of 45%.Major was Escherichia coli,and followed by Pseudomonas alcaligenes.The second generation of cephalosporin had a high sensitive rate to the bacteria.CONCLUSION:For the patients with successful laparoscopic cholecystectomy,no different effect occurs between 2 kinds of administration routes.