Detection and quantification of 5-hydroxyoxindole in mammalian sera and tissues by high performance liquid chromatography with multi-electrode electrochemical detection☆☆Abbreviations: ECD; electro chemical detection; PVDF; polyvinylidene fluoride; CSF; cerebrospinal fluid; QC; quality control; SPE; solid phase extraction; HLB; hydrophilic-lipophilic balance; pd; particle diameter; MAO; mono amine oxidase; SDS; sodium dodecyl sulfonate.
Clinical Biochemistry（2003）
摘要
Conclusion 5-hydroxyoxindole is an endogenous tryptophan metabolite present in circulating blood and in some tissues at the nmol level, its determination using HPLC-ECD will be useful for elucidating the role of this molecule in normal and disease conditions.
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关键词
5-hydroxyoxindole,Tryptophan,Oxindole,HPLC-ECD
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