1,3-Disubstituted-2-carboxy quinolones: highly potent and selective endothelin A receptor antagonists
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS(2000)
摘要
The design, synthesis, and in vitro biological activity of a series of 2-carboxy quinolone antagonists selective for the endothelin A receptor are presented. Introduction of a second acid group in position 3 of the quinolone ring increases dramatically the selectivity for ETA. (C) 2000 Elsevier Science Ltd. All rights reserved.
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biological activity
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