Comparison of the inhibitory effect of T-2 toxin on bovine platelet function with that of other known platelet inhibitors

The inhibitory effects of T-2 toxin on bovine platelet function and thromboxane A 2 production were compared with those of the known inhibitors of human platelet function, acetylsalicylic acid, dipyridamole and verapamil. T-2 toxin (1 × 10 −3 M) effectively inhibited bovine platelet aggregation (33.2–64.3%), whereas neither acetylsalicylic acid nor dipyridamole did so. T-2 toxin appeared to be a less effective inhibitor of platelet aggregation than the calcium channel blocker, verapamil. T-2 toxin (1 × 10 −3 M) added to platelet suspensions together with verapamil, produced an additive inhibitory response. T-2 toxin (2.5 × 10 −4 M) effectively inhibited the release of thromboxane A 2 from ADP-stimulated bovine platelets as did acetylsalicylic acid and verapamil but not dipyridamole. T-2 toxin appears to inhibit bovine platelets by a biochemical mechanism distinct from that of the other inhibitors.