Inflammation Causes Loss of Adeno-Associated Virus-Mediated Transgene Expression in Mouse Liver

Ekaterina Breous,Suryanarayan Somanathan,Peter Bell,James M. Wilson

Gastroenterology（2011）

引用 29|浏览6

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摘要

Conclusions Inflammation and inflammatory cytokines such as TNF-α can reduce AAV-mediated expression of transgenes in livers of mice. Inflammation might therefore affect expression of transgenes from viral vectors in humans.

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关键词

Hepatic Gene Therapy,Loss of Tolerance,Immune Response,Liver Inflammation

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