Synthesis and antibacterial activity of C12 des-methyl ketolides.

Xiaodong Lin,Alice C Rico,Daniel T Chu,Georgia L Carroll,Lynn Barker,Ribhi Shawar,Manoj C Desai,Jacob J Plattner

Bioorganic & Medicinal Chemistry Letters（2006）

引用 12|浏览11

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摘要

Synthesis of C12 des-methyl ketolides is developed featuring an intramolecular epoxide formation/elimination process to establish the C12 stereocenter. These ketolides are potent against several key respiratory pathogens including resistant strains.

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关键词

Macrolide,Ketolide,Antibacterial

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