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Syntheses and Anticancer Activity of Ribonucleoside Analogues Containing Thio-Substituted Five-Membered Heterocyclic Base

Y Ding,YY Zhang,J Zhang,YQ Chen

Bioorganic & medicinal chemistry letters（1997）

Cited 8|Views3
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Abstract
Syntheses of two types of ribonucleoside analogues with thio-substituted five-membered heterocyclic base have been carried out. The one contains thio-substituted 1,3,4-triazole as its base (2 to 7) and the other consists of amino-thio-thiadiazoline β-D-ribofuranosides (8 and 9). Biological evaluation showed that one (8) among them exhibited IC50 of 3.94 × 10−8 mol/L against NCI CNS cancer cell line SNB19.
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Triazole Synthesis
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