Non-aromatic A-ring replacement in the triaryl bis-sulfone CB2 receptor inhibitors

Bioorganic & Medicinal Chemistry Letters（2010）

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摘要

A-ring replacements of 1 were investigated leading to compound 53 which had good affinity for the human CB2 receptor, reduced affinity for the rat calcium channel, and an improved cytochrome P450 profile.

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关键词

CB2,Cannabinoid,Inverse agonist

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