Immunodeficiency with increased immunoglobulin M associated with growth hormone insufficiency.
Acta paediatrica (Oslo, Norway : 1992)(1993)
Abstract
Growth hormone deficiency associated with hypogammaglobulinemia has been reported only in a few publications. Our patient was a male with recurrent episodes of infections. Serum immunoglobulin (Ig) G was extremely low although IgM concentration was much greater than the normal limit. Growth hormone responses to insulin, 1-Dopa and growth hormone-releasing hormone were low. The mean growth hormone concentration during sleep was less than the normal limit. These results are consistent with hyper-IgM immunodeficiency associated with growth hormone deficiency. The mode of transmission appears to be autosomal dominant. This combination has not been reported previously.
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Key words
GROWTH HORMONE DEFICIENCY,HYPER-IGM SYNDROME,IMMUNODEFICIENCY,SHORT STATURE
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