559 Changes in pulmonary function after skin prick test with latex protein extracts

Marsdenia co,durango (MC) is a tree that belongs to the Ascleoadaceae family.Its berk is used in different countries as a medicinal plant.We describe a case of a subject sonsitised to latex that developed an anaphylaetic reaction after the first contact with an infusion that contained MC.A 32 yo woman had several episodes of nasal pruritus, sneezing, angioedema and urticaria after contact with latex gloves.She developed a severe anaphylactic reaction after taking an infusion containing camomile, marjoram, coriander, mint and MC.Skin test to 12 common inhalant allcrgons, marjoram, coriander, mint and camomile were negative and positive to latex, chesnut, banana and MC.Nine subjects allergic to latex were skin tested with MC and were positive in all cases.Skin tests were negative in a control group of ten subjects.Inhibition studies using RAST discs conjugated to latox showed cross-reactivity with MC.ELISA inhibition studies using rabbit antibodies to MC also showed cross-reactivity with latex.Allergy to latex is a growing phenomeno~ and cross-reactivity with allergcns of different nature has been repotted.The clinical symptoms of the subject after exposure to latex, the results of the skin tests, the immonochemical studies and the reaction to MC after first exposure indicate that the subject reacted to MC due to cross-resctivity with latex allergens.Since MC is a medicinal plant used for different purposes, subjects allergic to latex should he aware of the risks that may take after exposure to this plant.