MCP-1在难治性癫(癎)患者脑组织中的表达

Yuan WU,Xue-feng WANG,Zhi-qin XI,Fei XIAO,Jin-mei LI,Xi ZHU,Ji-jun SUN,Yun GONG,Feng-ying LIU,Guo-ming LUAN,Yu-ping WANG,Yun-lin LI,Jian-guo ZHANG,Yong LU,Hong-wei LI

Chinese Journal of Nervous and Mental Diseases（2006）

Cited 4|Views18

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Abstract

目的了解难治性癫(癎)患者脑组织中单核细胞趋化蛋白-1(monocyte chemoattractant protein-1,MCP-1)的表达,探索其在难治性癫(癎)发病机制中的作用.方法在基因芯片扫描获阳性结果基础上,用免疫组织化学方法研究40例难治性癫(癎)患者脑组织中MCP-1的表达,并与对照组进行比较.结果基因芯片扫描显示MCP-1 mRNA表达上调,免疫组化结果进一步证实MCP-1在难治性癫(癎)患者脑组织中的表达较对照组明显增多(P＜0.05).结论 MCP-1在难治性癫(癎)的发病机制中可能起着重要作用,阻断MCP-1有可能改变难治性癫(癎)的预后.

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Key words

Intractable epilepsy Monocyte chemoattractant protein-1 ( MCP-1) cDNA microarray Immumohistochemisry

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