OGG1 Ser326Cys多态性与结直肠癌发病风险的meta分析

目的对OGG1 Ser326Cys多态性与结直肠癌的关系做出更为准确的结论。方法通过对12篇文章采用meta分析评估OGG1 Ser326Cys多态性与结直肠癌发病率的关系。用合并比值比(OR)描述显性模型(Cys/Cys vs Ser/Ser;Ser/Cys vs Ser/Ser),主导模型(Ser/Cys+Cys/Cys vs Ser/Ser),隐性模型(Cys/Cys vs Ser/Cys+Ser/Ser)。结果 Cys/Cys vs Ser/Ser(OR=1.19,95%可信区间(CI)=0.92~1.53)、Ser/Cys vs Ser/Ser(OR=1.04,95%CI=0.95~1.13)、Ser/Cys+Cys/Cys vs Ser/Ser(OR=1.06,95%CI=0.98~1.16)和Cys/Cys vs Ser/Cys+Ser/Ser(OR=1.11,95%CI=0.90~1.38)无明显联系,此外,在分层分析中,所有基因型未见明显发病风险差异。结论 meta分析表明OGG1Ser326Cys多态性与结直肠癌总发病率无联系。